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Publications

Clinical Publications
Clinical Publications

2024

Feasibility and safety of endoscopic ultrasound-guided diffusing alpha emitter
radiation therapy for advanced pancreatic cancer: Preliminary data

2024

Extended Follow-Up Outcomes from Pooled Prospective Studies Evaluating Efficacy of Interstitial Alpha Radionuclide Treatment for Skin and Head and Neck Cancers

2023

Alpha DaRT technology harnessing the power of alpha particles for therapeutic use in fighting vulvar cancer

2023

Feasibility and Safety of Diffusing Alpha-Emitter Radiation Therapy for Recurrent or Unresectable Skin Cancers

2020

 

A Hard Target Needs a Sharper DaRT

2020

Initial Safety and Tumor Control Results from a “First-in-Human” Multicenter Prospective Trial Evaluating a Novel Alpha-Emitting Radionuclide for the Treatment of Locally Advanced Recurrent Squamous Cell Carcinomas of the Skin and Head and Neck

2019

Clinical evidence of abscopal effect in cutaneous squamous cell carcinoma treated with diffusing alpha emitters radiation therapy: a case report

Pre-Clinical Publications

2024

 

DNA damage response in a 2D-culture model by diffusing alpha-emitters radiation therapy (Alpha-DaRT)

2023

 

Bronchoscopic deployment and implantation of Diffusing alpha-emitters Radiation Therapy into the lung and mediastinum for treatment of lung cancer: a pre-clinical safety and feasibility study

2023

 

The low-LET radiation contribution to the tumor dose in diffusing alpha-emitters radiation therapy

2023

 

A finite element method for modeling diffusion of alpha-emitting particles in tissue

2022

Alpha dose modeling in diffusing alpha-emitters radiation therapy.

Part I: single-seed calculations in one and two dimensions

2022

Alpha dose modeling in diffusing alpha-emitters radiation therapy.

Part II: Lattice studies

2022

Diffusing alpha-emitters radiation therapy Promotes a Proimmunogenic Tumor Microenvironment and Synergizes With Programmed Cell Death Protein 1 Blockade

2022

Diffusing alpha-emitters radiation therapy in combination with temozolomide or bevacizumab in human glioblastoma multiforme xenografts

2022

A New Approach for a Safe and Reproducible Seeds Positioning for Diffusing Alpha-Emitters Radiation Therapy of Squamous Cell Skin Cancer: A Feasibility Study

2021

The Potentiation of Anti‐Tumor Immunity by Tumor Abolition with Alpha Particles, Protons, or Carbon Ion Radiation and Its Enforcement by Combination with
Immunoadjuvants or Inhibitors of Immune Suppressor Cells and Checkpoint Molecules

2020

Effective treatment of metastatic cancer by an innovative intratumoral
alpha particle-mediated radiotherapy in combination with
immunotherapy: A short review

2020

Diffusing alpha-emitters radiation therapy: approximate modeling of the
macroscopic alpha particle dose of a point source

2020

RIG-1-Like Receptor Activation Synergizes With Intratumoral Alpha Radiation to Induce Pancreatic Tumor Rejection, Triple-Negative Breast Metastases Clearance, and Antitumor Immune Memory in Mice

2019

Combining alpha radiation‑based brachytherapy with immunomodulators promotes complete tumor regression in mice via tumor‑specific long‑term immune response

2016

Inhibition of mouse breast adenocarcinoma growth by ablation with intratumoral alpha-irradiation combined with inhibitors of immunosuppression and CpG

2015

Tumor ablation by intratumoral Ra-224 loaded wires induces anti-tumor immunity against experimental metastatic tumors

2015

Ablation of experimental colon cancer by intratumoral 224 Radium-loaded wires is mediated by alpha particles released from atoms which spread in the tumor and can be augmented by chemotherapy

2014

Activation of local and systemic anti‑tumor immune responses by ablation of solid tumors with intratumoral electrochemical or alpha radiation treatments

2012

Intratumoral Ra-224-loaded wires spread alpha emitting atoms inside solid human tumors in athymic mice and can achieve local tumor control

2012

Enhanced killing of cervical cancer cells by combinations of methyl jasmonate with cisplatin, X or alpha radiation

2012

Comparative in vitro microdosimetric study of murine and human-derived cancer cells exposed to alpha particles

2012

Local control of experimental malignant pancreatic tumors by treatment with a combination of chemotherapy and intratumoral 224Radium-loaded wires releasing alpha-emitting atoms

2010

Treatment of solid tumors by alpha emitters released from 224Ra-loaded sources – internal dosimetry analysis

2009

Local control of lung derived tumors by diffusing alpha-emitting atoms released from intratumoral wires loaded with Radium-224

2009

Interstitial wires releasing diffusing alpha-emitters combined with chemotherapy improved local tumor control and survival in squamous cell carcinoma bearing mice

2008

Growth retardation and destruction of experimental squamous cell carcinoma by interstitial radioactive wires releasing diffusing alpha-emitting atoms

2007

Treatment of solid tumors by interstitial release of recoiling short-lived alpha emitters

Pre-Clinical Pubications
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