A. Popovtzer, MD, E. Rosenfeld, DMD, PhD, A. Mizrachi, MD, S.R. Bellia, MD, R. Ben-Hur, MA, G. Feliciani, PhD, A. Sarnelli, MA, L. Arazi, PhD, L. Deutsch, PhD, I. Kelson, PhD, Y. Keisari, PhD

Initial Safety and Tumor Control Results from a “First-in-Human” Multicenter Prospective Trial Evaluating a Novel Alpha-Emitting Radionuclide for the Treatment of Locally Advanced Recurrent Squamous Cell Carcinomas of the Skin and Head and Neck

Bellia, S. R., Feliciani, D., Del Duca, M., Monti, M., Turri, M., Sarnelli, A., Romeo, A., Kelson, I., Keisari, Y., Popovtzer, A., Ibrahim, T., Paganelli, G., Stanganelli, I.

Clinical evidence of abscopal effect in cutaneous squamous cell carcinoma treated with diffusing alpha emitters radiation therapy: a case report.

Domankevich, V., Cohen, A., Efrati, M., Schmidt, M., Rammensee, H-G., Nair, S. S., Tewari, A., Kelson, I., Keisari, Y. Cancer Immunol Immunother (2019).

Combining alpha radiation‑based brachytherapy with immunomodulators promotes complete tumor regression in mice via tumor‑specific long‑term immune response

Confino, H., Schmidt, M., Efrati, M., Hochman, I., Umansky, V., Kelson, I., Keisari, Y. Cancer Immunol Immunother. e-press Aug 06 2016. DOI: 10.1007/s00262-016-1878-6

Inhibition of mouse breast adenocarcinoma growth by ablation with intratumoral alpha-irradiation combined with inhibitors of immunosuppression and CpG

Reitkopf, S., Cooks, T., Schmidt, M., Efrati, M., Arazi, L., Rath-Wolfson, L., Marshak, G., Kelson, I., Keisari, Y. Int J Radiat Biol. Int J Radiat Biol. 91:179-186; 2015. doi: 10.3109/09553002.2015.959666.

Ablation of experimental colon cancer by intratumoral 224 Radium-loaded wires is mediated by alpha particles released from atoms which spread in the tumor and can be augmented by chemotherapy

Confino, H., Hochman, I., Efrati, M., Schmidt, M., Umansky, V., Kelson, I., Keisari, Y. Cancer Immunol Immunother. 2015; 64(2):191-9. doi: 10.1007/s00262-014-1626-8.

Tumor ablation by intratumoral Ra-224- loaded wires induces anti-tumor immunity against experimental metastatic tumors

Cooks, T., Tal, M., Raab, S., Efrati, M., Reitkopf, S., Lazarov, E., Etzyoni, R., Schmidt, M., Arazi, L., Kelson, I., Keisari, Y. Anticancer Res. 32(12): 5315-21; 2012.

Intratumoral Ra-224-loaded wires spread alpha emitting atoms inside solid human tumors in athymic mice and can achieve local tumor control

Milrot, E., Jackman, A., Flescher, E., Gonen, P., Kelson, I., Keisari, Y., Sherman, L. Invest. New Drugs. Epub 6 Sept. 2012.

Enhanced killing of cervical cancer cells by combinations of methyl jasmonate with cisplatin, X or alpha radiation

Lazarov, E., Arazi, L., Efrati, M., Cooks, T., Schmidt, M., Keisari, Y., Kelson, I. Radiat Res. 177: 280–287; 2012. [2011 Nov 11, Epub ahead of print]

Comparative in vitro microdosimetric study of murine and human-derived cancer cells exposed to alpha particles

Horev-Drori, G., Cooks, T., Bittan, H., Lazarov, E., Schmidt, M., Arazi, L., Efrati, M., Kelson, I., Keisari, Y. Transl. Res. 159: 32-41; 2012.

Local control of experimental malignant pancreatic tumors by treatment with a combination of chemotherapy and intratumoral 224Radium-loaded wires releasing alpha-emitting atoms

Arazi, L., Cooks, T., Schmidt, M., Keisari, Y., Kelson I. Phys. Med. Biol. 55: 1203-1218; 2010.

The treatment of solid tumors by alpha emitters released from 224Ra-loaded sources—internal dosimetry analysis

Cooks, T., Arazi, L., Efrati, M., Schmidt, M., Marshak, G., Kelson, I., Keisari, Y. Cancer 115: 1791-1801; 2009.

Interstitial wires releasing diffusing alpha-emitters combined with chemotherapy improved local tumor control and survival in squamous cell carcinoma bearing mice

Cooks, T., Schmidt, M., Bittan, H., Lazarov, E., Arazi, L., Kelson, I., Keisari, Y. Int. J. Rad. Oncol. Biol. & Phys. 74: 966-973; 2009.

Local control of lung derived tumors by diffusing alpha-emitting atoms released from intratumoral wires loaded with Radium-224

Cooks, T., Arazi, L., Schmidt, M., Marshak, G., Kelson, I., Keisari, Y. Int. J. Cancer 122: 1657-1664; 2008.

Growth retardation and destruction of experimental squamous cell carcinoma by interstitial radioactive wires releasing diffusing alpha-emitting atoms

Arazi, L., Cooks, T., Schmidt, M., Keisari, Y., Kelson, I. Phys. Med. Biol, 52: 5025-5042: 2007.

Treatment of solid tumors by interstitial release of recoiling short-lived alpha emitters

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